The "Haus Hufeland" used to serve as a lung sanatorium, a sanatorium which was run by the Schnurrer family for 40 years. It belonged to the property of the former Pension Blume, which was also used for lung care in the 1930s and 1940s. As a result of the Second World War, there were numerous patients with contagious pulmonary tuberculosis who had to be treated regularly for years. dr Schnurrer was chief physician of lung care.

The "Haus Hufeland" was named after the doctor Christoph Wilhelm Hufeland (1762 - 1836), who looked after Schiller and Goethe and finally became the personal doctor of Queen Luise of Prussia.  

On April 1, 1993, the Kurhaus and Hufeland-Klinik were officially transferred to the Asklepios-Kliniken GmbH based in Taunus, now as "Asklepios Burgseeklinik Bad Salzungen (Haus I und II)". 

On October 15, 2002, part of the recently renovated Haus Hufeland building burns down, the estimated damage is 700,000 euros.
In the fall of 2003, the first phase of the reconstruction of the Hufeland building was completed, which has since housed a hotel with an extension to Sulzberger Straße. In June 2004, the topping-out ceremony took place on the 3rd construction phase of the Hotel Haus Hufeland of the Asklepios Burgseekliniken.